手機(jī)版
化工儀器網(wǎng)手機(jī)版
化工儀器網(wǎng)小程序
官方微信
公眾號(hào)：chem17
掃碼關(guān)注視頻號(hào)
PPARα 系列PPARγ 及 PPARδ 系列 抑制劑 /激動(dòng)劑
Peroxisome proliferator-activated receptor alpha （PPARα） is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor （RXR） to regulate gene expression. PPARα is located primarily in the liver, adipose tissue, kidney, heart, skeletal muscle and large intestine where it is thought to regulate fatty acid synthesis and oxidation, gluconeogenesis, ketogenesis and lipoprotein assembly. The human gene encoding PPARα has been localized to chromosome 22 （22q12-13.1）.
Species Gene Symbol Gene Accession No. Protein Accession No.
Human PPARA NM_001001928 Q07869
Mouse Ppara NM_011144 P23204
Rat Ppara NM_013196 P37230
抑制劑
GW 6471
分子量:635.68 分子式:C35H36F3N3O5
Solubility:Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:>98 % 10mg ，50mg 規(guī)格
CAS No:[436159-64-7]
Chemical Name:[（2S）-2-[[（1Z）-1-Methyl-3-oxo-3-[4-（trifluoromethyl）phenyl]-1-propenyl]amino]-3-[4-[2-（5-methyl-2-phenyl-4-oxazolyl）ethoxy]phenyl]propyl]-carbamic acid ethyl ester
Sold with the permission of GlaxoSmithKline 過氧化物酶增殖活化受體α抑制劑 GW6471 PPARα 系列產(chǎn)品
PPARα抑制劑 that inhibits activation with an IC50 value of 0.24μM.
MK 886
分子量:472.08 分子式:C27H34ClNO2S
Solubility:Soluble to 5 mM in ethanol and to 100 mM in DMSO
Purity:>98 % 10mg ，50mg 規(guī)格
Storage:Store at RT
CAS No:[118414-82-7]
Chemical Name: 1-[（4-Chlorophenyl）methyl]-3-[（1,1-dimethylethyl）thio]-α,α-dimethyl-5-（1-methylethyl）-1H-Indole-2-propanoic acid
別名：L-663,536
An inhibitor of leukotriene biosynthesis （IC50 = 3 nM in human polymorphonuclear leukocytes）. Acts by inhibiting 5-lipoxygenase-activating protein （FLAP） （IC50 = 30 nM for inhibition of [125I]-L-691,678 photoaffinity labelling）. Also moderay potent PPARα抑制劑 （IC50 = 0.5-1μM）. Orally activein vivo.
激動(dòng)劑
GW 7647
分子量:502.75 分子式：C29H46N2O3S
Solubility:Soluble to 25 mM in ethanol and to 100 mM in DMSO
Purity:>99 % 10mg ，50mg 規(guī)格
CAS No:[265129-71-3]
Chemical Name: 2-[[4-[2-[[（Cyclohexylamino）carbonyl]（4-cyclohexylbutyl）amino]ethyl]phenyl]thio]-2-methylpropanoic acid
Potent and highly selective PPARαagonist （EC50 values are 6, 1100 and 6200 nM for human PPARα, PPARγand PPARδreceptors respectively）. Modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubulesin vitro. Has lipid-lowering effects following oral administrationin vivo. Reduces NO production in macrophages; exhibits anti-inflammatory properties
Fenofibrate
分子量：360.83 分子式：C20H21ClO4
Solubility:Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:>99 % 50mg 規(guī)格
Storage:Store at RT
CAS No:[49562-28-9]
Chemical Name: 2-[4-（4-Chlorobenzoyl）phenoxy]-2-methylpropanoic acid isopropyl ester
PPARα agonist; hypolipidemic. Attenuates insulin resistance and increases high-density lipoprotein-cholesterol in db/db mice.
296638 [49562-28-9] Fenofibrate
294030 Fenofibrate Imp. F （EP）: （4-Chlorophenyl）[4-（1-methyl-ethoxy
294029 Fenofibrate Imp. E （EP）: Ethyl 2-[4-（4-Chlorobenzoyl）-phenox
294028 Fenofibrate Imp. D （EP）: Methyl 2-[4-（4-Chlorobenzoyl）-pheno
294027 Fenofibrate Imp. C （EP）: （3RS）-3-[4-（4-Chlorobenzoyl）-phenox
294026 Fenofibrate Imp. A （EP）: （4-Chlorophenyl）（4-hydroxyphenyl）me
294025 Fenofibrate
290762 Fenofibrate impurity G
290761 Fenofibrate impurity B
290760 Fenofibrate impurity A
290759 Fenofibrate
288620 [49562-28-9] Fenofibrate
261137 Fenofibrate-d6
261136 49562-28-9 Fenofibrate
259465 Dihydro Fenofibrate-d6
259464 61001-99-8 Dihydro Fenofibrate
257408 856676-23-8 Choline Fenofibrate
Oleylethanolamide
分子量:325.53 分子式：C20H39NO2
Purity:>99 % 10mg ，50mg 規(guī)格
Storage:Store at +4°C
CAS No:[111-58-0]
Chemical Name: （9Z）-N-（2-Hydroxyethyl）-9-octadecenamide
Palmitoylethanolamide
分子量：299.5 分子式：C18N37NO2
Solubility:Soluble to 20 mM in DMSO and to 25 mM in ethanol
Storage:Store at RT 10mg ，50mg 規(guī)格
CAS No:[544-31-0]
別名: PEA Chemical Name: N-（2-Hydroxyethyl）hexadecanamid
WY 14643
分子量：323.8 分子式：C14H14ClN3O2S
Solubility:Soluble to 100 mM in DMSO
Purity:>98 % 10mg ，50mg 規(guī)格
Storage:Store at RT
CAS No:[50892-23-4]
Chemical Name: [[4-Chloro-6-[（2,3-dimethylphenyl）amino]-2-pyrimidinyl]thio]acetic acid
其它相關(guān)產(chǎn)品：
PPARγ
Peroxisome proliferator-activated receptor gamma （PPARγ） is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor （RXR） to regulate gene expression. PPARγ is located primarily in the adipose tissue, lymphoid tissue, colon, liver and heart and is thought to regulate adipocyte differentiation and glucose homeostasis. PPARγ has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. The human gene encoding PPARγ has been localized to chromosome 3 （3p25）.
PPARγ Products
激動(dòng)劑
Ciglitazone
Selective PPARγ agonist
GW 1929 hydrochloride
Selective PPARγ agonist. Orally active
LG 100754
M.Wt:396.56 Formula:C26H36O3
Solubility:Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:>99 % 10mg ，50mg 規(guī)格
CAS No:[180713-37-5]
Chemical Name: （2E,4E,6Z）-3-Methyl-7-（5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl）-2,4,6-octatrienoic acid
Novel RXR:PPARγagonist; sensitizes PPARγby enhancing its ligand binding activity. Also activates RXR:RAR and RXR:PPARαheterodimers in cotransfection assays. Displays selectivity over other permissive heterodimers such as RXR:LXRαand RXR:BAR/FXR. Exhibits antidiabetic propertiesin vivo.
nTZDpa
Potent, selective PPARγ partial agonist
Pioglitazone hydrochlorideNew product
Selective PPARγ agonist; antidiabetic agent
15-deoxy-Δ-12,14-Prostaglandin J2
Endogenous PPARγ agonist
S26948New productPrices displayed reflect a 25% discount off list price
Selective PPARγ agonist; antidiabetic agent
Troglitazone
Selective PPARγ agonist; antidiabetic agent
Ant激動(dòng)劑：
BADGE
PPARγ 抑制劑
GW 9662 Selective PPARγ 抑制劑
分子量：276.68
分子式：C13H19N2O3Cl
Solubility:Soluble to 25 mM in ethanol
Purity:>98 % 10mg ，50mg 規(guī)格
Storage:Store at RT
CAS No:[22978-25-2]
Chemical Name: 2-Chloro-5-nitro-N-phenylbenzamide
Selective PPARγ 抑制劑 （IC50 values are 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively）. Blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range （1-2 μM）, therefore is more potent than BADGE . Anticancer, inhibits growth of human mammary tumor cell lines.
SR 202
Selective PPARγ 抑制劑; antidiabetic and antiobesity agent
T 0070907
Highly potent and selective PPARγ 抑制劑
Other
Genistein
PPARγ ligand. Also estrogen receptor ligand and EGFR inhibitor
Peroxisome proliferator-activated receptor delta （PPARδ）, also known as PPARβ, is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor （RXR） to regulate gene expression.
PPARδ displays a ubiquitous expression pattern and is thought to regulate placental and gut development, fatty acid oxidation, adaptive thermogenesis, control of cell proliferation and differentiation and tissue repair. The human gene encoding PPARδ has been localized to chromosome 6 （6p21.2）.
PPARδ Products
激動(dòng)劑
GW 0742
Highly selective, potent PPARδ agonist
L-165,041
Potent PPARδ agonist
Ant激動(dòng)劑
GSK 0660
Selective PPARδ 抑制劑
GSK 3787
Potent and selective PPARδ 抑制劑
Modulators
Retinoic acid
Positive modulator of PPARδ. Also retinoic acid receptor agonist
Antibodies and Blocking Peptides
Anti-PPARδ
Antibody recognizing PPARδ
相關(guān)產(chǎn)品
免責(zé)聲明
- 凡本網(wǎng)注明“來源：化工儀器網(wǎng)”的所有作品，均為浙江興旺寶明通網(wǎng)絡(luò)有限公司-化工儀器網(wǎng)合法擁有版權(quán)或有權(quán)使用的作品，未經(jīng)本網(wǎng)授權(quán)不得轉(zhuǎn)載、摘編或利用其它方式使用上述作品。已經(jīng)本網(wǎng)授權(quán)使用作品的，應(yīng)在授權(quán)范圍內(nèi)使用，并注明“來源：化工儀器網(wǎng)”。違反上述聲明者，本網(wǎng)將追究其相關(guān)法律責(zé)任。
- 本網(wǎng)轉(zhuǎn)載并注明自其他來源（非化工儀器網(wǎng)）的作品，目的在于傳遞更多信息，并不代表本網(wǎng)贊同其觀點(diǎn)和對(duì)其真實(shí)性負(fù)責(zé)，不承擔(dān)此類作品侵權(quán)行為的直接責(zé)任及連帶責(zé)任。其他媒體、網(wǎng)站或個(gè)人從本網(wǎng)轉(zhuǎn)載時(shí)，必須保留本網(wǎng)注明的作品第一來源，并自負(fù)版權(quán)等法律責(zé)任。
- 如涉及作品內(nèi)容、版權(quán)等問題，請(qǐng)?jiān)谧髌钒l(fā)表之日起一周內(nèi)與本網(wǎng)聯(lián)系，否則視為放棄相關(guān)權(quán)利。
采購中心