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Analysis (klEA) database and screened them for those associated with colorectal cancer prognosis, with the final list including ALqwa, GPC1, ALDOC, and SLC2A3. Using the sum of the expression levels of these four genes, provided by The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, and the expression coebdgcients, we developed a hypoxia risk score model. Using the median risk score value, we divided