UA040222 MIG/CXCL9 Protein, Human
- 公司名稱 杭州斯達特生物科技有限公司
- 品牌 Starter/斯達特
- 型號 UA040222
- 產(chǎn)地 江蘇 南京
- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時間 2025/7/3 10:00:58
- 訪問次數(shù) 34
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Monokine induced by IFN-gamma （MIG; CXC chemokine ligand （CXCL）9） is important in T lymphocyte recruitment in organ transplantation.
MIG/CXCL9 stimulate CD4 lymphocyte proliferation in a MHC class II-mismatched MLR and also increased the number of IFN-gamma-producing CD4 lymphocytes in ELISPOT. Neutralization of MIG/CXCL9 in MLR reduced T lymphocyte proliferation, IFN-gamma-inducible protein 10/CXCL10 and IFN-inducible T cell alpha chemoattractant/CXCL11 had similar effects on T lymphocyte proliferation. MIG/CXCL9 stimulated T lymphocyte proliferation in MHC class I-and total MHC-mismatched MLRs. Neutralization of CXCR3 reduced MIG/CXCL9-induced T lymphocyte proliferation and the number of IFN-gamma-positive spots on ELISPOT.The proliferative effects of MIG/CXCL9 were mediated via an IL-2-independent pathway and were controlled by IFN-gamma.
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