UA040116 FGF-12 Protein, Human
- 公司名稱 杭州斯達(dá)特生物科技有限公司
- 品牌 Starter/斯達(dá)特
- 型號 UA040116
- 產(chǎn)地 江蘇 南京
- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時(shí)間 2025/7/3 7:51:20
- 訪問次數(shù) 33
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Fibroblast growth factor 12 (FGF-12), also known as fibroblast growth factor homologous factors (FHF), is cytosolic proteins that is homologous to fibroblast growth factors but is not secreted. FGF12 modulates both cardiac Na+ and Ca+ channel by binding to the conserved proximal part of the C-terminal domain of voltage-gated sodium channels Nav1.5. However, a single missense mutation in FGF12-B (Q7R-FGF12) reduced binding to the NaV1.5 C-terminus, yielding a Brugada Syndrome phenotype.