CLI-095 Resatorvid瑞沙托維 TAK-242
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- 型號 CLI-095
- 產地
- 廠商性質 生產廠家
- 更新時間 2019/7/10 13:26:10
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抑制劑，調節劑，API，天然產物，各種類型化合物庫
| 供貨周期 | 現貨 | 規格 | 10 mM * 1 mL;5mg;10mg;50mg;100mg;200mg |
|---|---|---|---|
| 貨號 | HY-11109 | 應用領域 | 生物產業 |
Resatorvid瑞沙托維 TAK-242
MCE 站：Resatorvid
產品活性：Resatorvid (TAK-242) 是一種有效的 TLR4 信號傳導抑制劑，可選擇性地抑制TLR-介導的細胞因子和一氧化氮的產生。
研究領域：Immunology/Inflammation | Autophagy
作用靶點：Toll-like Receptor (TLR) | Autophagy
Resatorvid瑞沙托維 TAK-242
In Vitro: In RAW264.7 cells and mouse peritoneal macrophages, Resatorvid (TAK-242) suppresses lipopolysaccharide (LPS)-induced production of NO, tumor necrosis factor-α (TNF-α), and interleukin (IL)-6, with IC50 of 1.1 to 11 nM. Resatorvid (TAK-242) also suppresses the production of these cytokines from LPS-stimulated human peripheral blood mononuclear cells (PBMCs) at IC50 values from 11 to 33 nM.
In Vivo: Resatorvid (TAK-242) apparently reduces the serum anti-dsDNA levels in both genotype mice. Alternatively, IFN-γ, TNF-α, and IL-1β production is markedly inhibited by Resatorvid (TAK-242), but their concentrations are still greatly higher than those in NS-treated counterparts. Resatorvid (TAK-242) pre-stress administration prevents the accumulation of potentially deleterious inflammatory and oxidative/nitrosative mediators in the brain frontal cortex of rats. Resatorvid (TAK-242) i.v. administration at the beginning of the stress session completely blocks TLR-4 mRNA and protein upregulation after stress exposure.
相關產品：Drug Repurposing Compound Library | Clinical Compound Library | Clinical Compound Library Plus | CNS-Penetrant Compound Library | Small Molecule Immuno-Oncology Compound Library | Drug Repurposing Compound Library Plus | Bioactive Compound Library Plus | Autophagy Compound Library | Immunology/Inflammation Compound Library | Chloroquine diphosphate | Resiquimod | C29 | Hydroxychloroquine sulfate | Imiquimod | Vesatolimod | Motolimod | CU-CPT22 | Atractylenolide I | E6446 dihydrochloride | Paquinimod | TLR7/8 agonist 1 dihydrochloride | CU-CPT17e | Gardiquimod trifluoroacetate | Telratolimod | MD2-IN-1 | Procyanidin B1 | CU-CPT-8m | CU-CPT-9a | CU-CPT-9b | Toll-like receptor modulator | PF-4878691 | AN-3485 | IAXO-102 | LHC-165 | MMG-11 | Neoseptin 3
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