Also known as：B220; CD 45; GP180; L CA; LCA; Leukocyte common antigen; LY5; Protein tyrosine phosphatase receptor type C; Protein tyrosine phosphatase receptor type c polypeptide; protein tyrosine phosphatase, receptor type, C; PTPRC; SCID due to PTPRC deficiency; T200; T200 glycoprotein.

Background：  CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms (220, 205, 190, 180 kDa) which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage (including hematopoietic stem cells) with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions. Antibodies recognising a common epitope on all of the isoforms are termed CD45 whilst those recognising only individual isoforms are termed CD45RA or CD45RO etc.

Sepcificity:     Rabbit polyclonal IgG,affinity purified by Protein A.

              Alexa Fluor 555 conjugated.

              Reacts with:Human,mouse,rat,chicken,dog,cow,horse

              Immunogen: KLH conjugated synthetic peptide derived from human CD45/B220

              Predicted molecular weight:141kDa.

Application:   IF=1:50-200,ICC=1:50-200

              Excitation spectrum:555nm

              Emission spectrum:565nm

              Not yet tested in other applications.

              Optimal working dilutions must be determined by the end user.

上海安研，提供CD45抗體相對應的抗原

CD45抗原

CD45 antigen