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CD150, also known as SLAM （Signaling Lymphocytic Activation Molecule）, is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily and encoded by the SLAMF1 gene. It is primarily expressed on various hematopoietic cells, including T cells, B cells, natural killer cells, dendritic cells, monocytes, and macrophages. CD150 serves multiple functions: it acts as a co-stimulatory molecule in immune cell activation, a receptor for morbilliviruses such as measles virus, and a bacterial sensor on macrophages. The protein has several isoforms, including a transmembrane form （mCD150）, a secreted form （sCD150）, and a novel transmembrane form （nCD150） with an alternative cytoplasmic tail. CD150 mediates homophilic interactions and can transmit either activating or inhibitory signals depending on the cell type and context.