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Mitogen-activated protein kinase kinases 1 and 2 （MEK1/2） are the crucial part of the RAS-RAF-MEK-ERK pathway （or ERK pathway）, which is involved in the regulation of various cellular processes including proliferation, survival, and differentiation et al. Targeting MEK has become an important strategy for cancer therapy, and 4 MEK inhibitors （MEKis） have been approved by FDA to date [PMID: 33774345].