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商品信息

產品英文名稱	Human IL-10 Protein
產品中文名稱	10（IL-10）
別名	CSIF; IL10A; TGIF; Cytokine Synthesis Inhibitory Factor; IL10; IL-10; IL 10

商品屬性

標簽	無標簽
表達宿主	大腸桿菌
種屬	人
序列	氨基酸序列來源于：人源IL 10 (Ser19-Asn178) (P22301) 表達的蛋白片段。
活性	Testing in Progress
蛋白長度	重組人 IL10由161個氨基酸組成，預測分子量為18.78 KD。
純度	> 97% ，使用SDS-PAGE檢測
特點&優勢	通過LAL法測定，每微克蛋白里內毒素含量<1.0>
產品形式	凍干粉，凍干緩沖液為無菌的20 mM Tris，150 mM NaCl，pH 7.4。
基因ID	3586
蛋白序列鏈接	https://www.ncbi.nlm.nih.gov/protein/NP_000563.1,NP_001369553.1
使用中注意事項	開蓋使用前，請先離心。本產品為凍干粉，推薦用該產品配套的Reconstitution Buffer進行復溶，且濃度不低于100 µg/mL。客戶可根據后續的實驗需求，進行進一步的稀釋。
保存建議	本產品為凍干粉形式，建議：將凍干粉產品保存于-20℃以下的干燥環境中。本產品溶解之后，可在4℃保存2-7天，長期使用請置于-20℃以下。為長期保存，推薦添加載體蛋白（0.1% HAS/BSA或10%FBS），并酌情分裝保存，避免反復凍融。
運輸條件	冰袋運輸（藍冰）
警告	本文列出的產品僅供研究使用，不適用于人類或臨床診斷。我們產品所推薦應用，不是建議使用我們的產品去違反任何或許可證。對于使用本產品可能發生的侵權或其他違規行為，我們不承擔任何責任。

附加信息

背景

IL-10 is an anti-inflammatory cytokine that belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells, and other cell types, while it is produced primarily by monocytes and to a lesser extent by lymphocytes. IL-10 is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and also in a certain subset of activated T cells and B cells. IL-10 has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. The importance of interleukin 10 for counteracting excessive immunity in the human body is revealed by the fact that patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant IL-10. IL-10 inhibits the synthesis of some cytokines, including IFN-gamma, IL-2, IL-3, TNF, and GM-CSF produced by activated macrophages and by helper T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen-presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production.

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