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Laduviglusib (GMP)

CAS No. : 252917-06-9

產品活性：Laduviglusib (CHIR-99021) (GMP) is Laduviglusib (HY-10182) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Laduviglusib is a potent, orally active and selective GSK-3α/β inhibitor.

研究領域：PI3K/Akt/mTOR  |  Stem Cell/Wnt  |  Autophagy

作用靶點：GSK-3  |  Wnt  |  β-catenin  |  Autophagy

In Vitro: Laduviglusib (GMP) (20 μM, 21 days) transdifferentiates mouse fibroblasts to neurons (determined by increased number of TAUEGFP-/TUJ1-positive neuronal cells).
Laduviglusib (GMP) (3-5?μM, 2 days) induces somatic cells differentiation of pluripotent stem (PS) cells (the detailed method refers to the reference).
Laduviglusib (GMP) (12?μM, 5 days) converts human fibroblasts (HFF) into functional cardiomyocytes.
Laduviglusib (GMP) (3 μM, 4 days, hESCs) activates the canonical WNT signaling pathway, confirmed by β-catenin translocation into the nucleus.
Laduviglusib (GMP) (in MEFs expressing MyoD) enhances the marked increase in the number of proliferative cells led by RepSox (GMP) (HY-13012G) together with Forskolin (HY-15371).
Laduviglusib (GMP) (5 μM, 1 day) can be used to generate islets (hCiPSC-islets) from human chemically induced pluripotent stem cells (hCiPSC).

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