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MnTE-2-PyP chloride

CAS No. : 219818-60-7

產(chǎn)品活性：MnTE-2-PyP (BMX-010) chloride is a ROS scavenger and potent radioprotector. MnTE-2-PyP also is a manganese porphyrin, protects normal prostate tissue from radiation damage. MnTE-2-PyP can be used for the research of diabetic prostate cancer.

研究領(lǐng)域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶點：Reactive Oxygen Species

In Vitro: MnTE-2-PyP (30 μM) protects against hyperglycemiainduced cell death after radiation.
MnTE-2-PyP (30 μM) decreases expression of NOX4 and a-SMA, one of the major oxidative enzymes and pro-fibrotic molecules respectively.
MnTE-2-PyP (30 μM, 5 days) obstructs NF-kB activity by decreasing DNA binding of the p50-p50 homodimer in the irradiated hyperglycemic environment.
MnTE-2-PyP (30 μM) increases NRF2 mediated cytoprotection by increasing NRF2 protein expression and DNA binding.

In Vivo: MnTE2-PyP decreases tumor volume and increases survival in vivo mouse model of prostate cancer.
MnTE-2-PyP reduces blood glucose and inhibits pro-fibrotic signaling in a diabetic model.

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