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產品英文名稱:ALK-5 Inhibitor
產品中文名稱:ALK-5 抑制劑
ALK-5 產品英文簡述:
A selective inhibitor of ALK5 （TGF-beta type I receptor）. It has also been shown that this compound can replace Sox2 when reprogramming cells to iPS cells. 2-（3-（6-METHYLPYRIDIN-2-YL）-1H-PYRAZOL-4-YL）-1,5-NAPHTHYRIDINE
Ref: Gellibert, F., et al. （2004） Identification of 1, 5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem 47: 4494-4506. Ichida, J.K., et al. （2009） A small-molecule inhibitor of Tgf-beta signaling replaces Sox2 in reprogramming by inducing Nanog. Cell Stem Cell 5: 491-503
Purity: Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological Activity :Not determined.
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