首頁 >> 供求商機(jī)
貨物所在地：上海上海市
所在地： 美國StemRD公司
更新時(shí)間：2025-01-20 09:27:51
瀏覽次數(shù)：47
在線詢價(jià)收藏產(chǎn)品( 聯(lián)系我們，請(qǐng)說明是在 化工儀器網(wǎng) 上看到的信息，謝謝！）
產(chǎn)品英文名稱: IWP-2
產(chǎn)品中文名稱: IWP-2
IWP-2 產(chǎn)品英文簡述:
IWP-2:N-（6-Methyl-2-benzothiazolyl）-2-[（3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl）thio]-acetamide, is a specific inhibitor of the O-acyltransferase Porcupine with IC50=27nM （Ref.）. Inhibition blocks the production of Wnt proteins that require fatty acid modifications, thus disrupting Wnt-dependent signaling. Porcupine inhibitor represent a novel class of potential therapeutics for cancer and other WNT dependent diseases.
Ref: B. Chen, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat. Chem. Biol. 5, 100 （2009）
Purity: Greater than 99.5% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological Activity: In a cell-based assay measuring the activation of the TCF reporter gene, this compound gives IC50 of 30 nM.
如果想了解更多華雅干技術(shù)有限公司在中國代理銷售系列產(chǎn)品，咨詢與購買！
：勾娜娜
：
:
(空格分隔,最多3個(gè),單個(gè)標(biāo)簽最多10個(gè)字符)
會(huì)員.png)
6