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產品英文名稱:WNT-3a,Mouse
產品中文名稱:鼠重組WNT-3a蛋白
WNT-3a,Mouse 產品介紹:
wnt通路是細胞增殖分化的關鍵調控環節， 在胚胎發育和腫瘤發生中起著重要作用。wnt途徑參與了基因表達調節、 細胞遷移粘附、細胞極化等過程，同時還與其它信號通路存在交叉協同。Wnt/β-catenin通路在進化過程中高度保守，此通路的主要分子構成及相關調 控機制已得到基本闡明。對神經系統而言已有足夠證據顯示此通路參與了對神經前體細胞增殖， 分化以及決定細胞命運的調控。
Wnt-3a是Wnt基因家族中重要成員，zui近的一些研究發現， Wnt-3a信號蛋白對神經干細胞的定向分化的調控作用表現的十分明顯。小鼠WNT-3a蛋白包含328個氨基酸。
WNT-3a,Mouse產品特性:
? WNT-3a,Mouse活性經過NIH 3T3 細胞鑒定，純度高
? 生物活性在NIH 3T3 細胞經過TCF報告基因實驗鑒定The EC50為 50–150 ng/ml
? WNT-3a,Mouse產品經過SDS-PAGE 和HPLC雙層鑒定純度大于90%
? 只限于研究,非人體使用
WNT-3a,Mouse 產品英文簡述:
WNT-3a is a member of the WNT family of signaling proteins that play a key role in embryonic development and the integrity of adult tissues. WNT-3a is a prototypic canonical WNT that signals through the β-catenin pathway. The predicted size of mouse WNT-3a is a monomeric protein containing 333 amino acid residues. Due to glycosylation, it migrates at an apparent molecular weight of 40 kDa by SDS-PAGE analysis under nonreducing conditions. StemRD’s product is expressed from a mouse cell line overexpressing mouse WNT-3a. Purification is performed with a proprietary process that is distinct from the published method.
? Purity: Greater than 90% as determined by SDS-PAGE analysis
? Biological Activity: The activity was determined by using a TCF reporter gene assay in NIH3T3 cells. The EC50 ranges from 50 - 150 ng/ml. Country of Origin USA
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