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BioXcell：InVivoMAb anti-mouse CSF1R (CD115)

閱讀：648 發(fā)布時(shí)間：2022-8-1

一、產(chǎn)品介紹
落刺激因子1受體(CSF1R)，也稱為巨噬細(xì)胞集落刺激因子受體(M-CSFR)，即CD115反應(yīng)。CSF1R是一種單程I型膜蛋白，是血小板衍生生長(zhǎng)因子受體家族的成員。在小鼠中，CSF1R由單核細(xì)胞/巨噬細(xì)胞、腹膜滲出物細(xì)胞、漿細(xì)胞樣和常規(guī)樹突細(xì)胞以及破骨細(xì)胞表達(dá)。CSF1R是CSF1的受體，CSF1R通過CSF1R調(diào)節(jié)單核細(xì)胞譜系中細(xì)胞的增殖和分化。據(jù)報(bào)道，克隆號(hào)AFS98抗體可在體內(nèi)deplete巨噬細(xì)胞并阻斷CSFR1。

二、產(chǎn)品詳情

產(chǎn)品詳情
產(chǎn)品貨號(hào)	BE0213
產(chǎn)品規(guī)格	1/5/25/50/100mg
抗體亞型	Rat IgG2a, κ
推薦同型對(duì)照	InVivoMAb rat IgG2a isotype control, anti-trinitrophenol（貨號(hào)：BE0089）
推薦抗體稀釋液	InVivoPure™ pH 7.0 Dilution Buffer（貨號(hào)：IP0070）
免疫原	Not available or unknown
應(yīng)用	in vivo macrophage depletion/in vitro CSF1R neutralization/in vivo monocyte depletion/Flow cytometry/Western blot
產(chǎn)品形式	PBS , pH 7.0 Contains no stabilizers or preservatives
內(nèi)毒素水平	<2EU/mg (<0.002EU/μg) 使用 LAL gel clotting 測(cè)定
純度	>95% Determined by SDS-PAGE
無菌處理	0.2 μM filtered
生產(chǎn)形式	從組織培養(yǎng)上清液中純化得到。
純化形式	Protein G
RRID	AB_2687699
分子量大小	150 kDa
保存條件	抗體原溶液應(yīng)保存在4°C條件下，不要冷凍保存。

三、已發(fā)表文獻(xiàn)

用途	已發(fā)表文獻(xiàn)
in vivo macrophage depletion	Bauche, D., et al. (2018). “LAG3(+) Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1(+) Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis." Immunity 49(2): 342-352 e345
in vivo macrophage depletion	Gordon, S. R., et al. (2017). “PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity." Nature 545(7655): 495-499
in vivo macrophage depletion	Moynihan, K. D., et al. (2016). “Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses." Nat Med. doi: 10.1038/nm.4200
in vivo macrophage depletion	Arnold, I. C., et al. (2015). “CD11c monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23." Mucosal Immunol. doi: 10.1038/mi.2015.65
in vivo macrophage depletion	Kaminsky, L. W., et al. (2015). “Redundant Function of Plasmacytoid and Conventional Dendritic Cells Is Required To Survive a Natural Virus Infection." J Virol 89(19): 9974-9985
in vivo monocyte depletion	Naik, S., et al. (2015). “Commensal-dendritic-cell interaction specifies a unique protective skin immune signature." Nature 520(7545): 104-108
in vitro CSF-R1 neutralization	Sheng, K. C., et al. (2014). “IL-3 and CSF-1 interact to promote generation of CD11c+ IL-10-producing macrophages." PLoS One 9(4): e95208.
in vivo monocyte depletion	Greter, M., et al. (2012). “GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells." Immunity 36(6): 1031-1046.
in vivo macrophage depletion	Tagliani, E., et al. (2011). “Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1." J Exp Med 208(9): 1901-1916
in vivo macrophage depletion	Lim, A. K., et al. (2009). “Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice." Diabetologia 52(8): 1669-1679.