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上海源葉生物科技有限公司
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更新時間：2025-05-15 21:46:00瀏覽次數：169
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- 產品描述： Pioglitazone (U 72107) is an orally active and selective PPARγ (peroxisome proliferator-activated receptor) agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone can be used in diabetes research
- 靶點： hPPARγ:0.93 μM (EC50);mouse PPARγ:0.99 μM (EC50);hPPARδ:43 μM (EC50);hPPARα:100 μM (EC50);mouse PPARα:100 μM (EC50)
- 體內研究： Pioglitazone (oral gavage, 10 or 30 mg/kg, once daily, 14 days) can induce improvements in insulin resistance and diabetes that may be lipocalin-dependent in the liver but not in skeletal muscle. Pioglitazone (oral gavage, 10 mg/kg, once daily, 4 weeks) can significantly reduce body weight (BW), cardiac hypertrophy, elevated blood glucose levels and improve the associated dyslipidemia.
- 參考文獻：
1. Kuwabara K, et al. A novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose leve 2. Puddu A, et al. Pioglitazone attenuates the detrimental effects of advanced glycation end-products in the pancreatic beta cell line HIT-T15. Regul Pept. 2012 Aug 20;177(1-3):79-84. 3. Kubota N, et al. Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem. 2006 Mar 31;281(13):8748-55. 4. Elrashidy RA, et al. Pioglitazone attenuates cardiac fibrosis and hypertrophy in a rat model of diabetic nephropathy. J Cardiovasc Pharmacol Ther. 2012 Sep;17(3):324-33.
- 溶解度： DMSO : 40 mg/mL (112.22 mM; ultrasonic and warming and heat to 60°C)
- 保存條件： 2-8℃
- 配置溶液濃度參考：
1mg 5mg 10mg 1 mM 2.545 ml 12.726 ml 25.452 ml 5 mM 0.509 ml 2.545 ml 5.09 ml 10 mM 0.255 ml 1.273 ml 2.545 ml 50 mM 0.051 ml 0.255 ml 0.509 ml
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