聯系電話
上海起發實驗試劑有限公司
中級會員·16年
- 聯系人：
- 楊經理
- 電話：
- 021-50724187 021-50724961
- 手機：
- 15921799099
- 傳真：
- 021-50724961
- 地址：
- 上海浦東川沙鎮川沙路6619號上海起發實驗試劑有限公司
- 個性化：
- www.qfbio.com
- 網址：
- www.qfbio.com
掃一掃訪問手機商鋪
在新一期《美國科學院院報》上的一項研究表明，母性照顧可能通過一個大腦受體影響焦慮和體重。神經遞質神經肽Y幫助控制哺乳動物的焦慮、食欲和能量平衡；然而把小鼠大腦的為這種神經遞質的受體編碼的基因*去除似乎幾乎不會影響到生理。
為了進一步探索這種受體對焦慮和體重的影響，Carola Eva及其同事改造了小鼠，讓它的這種受體可以在大腦的邊緣系統選擇性地關閉-邊緣系統幫助控制情緒和焦慮。這組作者報告說，這種改造后的小鼠更加焦慮，擁有的脂肪組織更少，而且體重比對照小鼠更低，但是只有在這些小鼠被一種已知能夠提供細致的母性照顧，其標志是積極的弓背看護行為、在幼崽身邊蹲下的次數增加，以及個人梳理毛皮和筑巢的活動減少，這樣的育兒鼠品種撫養的情況下才會出現這種情況。當這些經過改造的小鼠幼崽被另一種已知母性照顧較少的小鼠品種養育的時候，它們幾乎沒有表現出焦慮和體重方面的明顯效應，這提示邊緣系統中的這種受體的制造取決于母性照顧。這組作者說，這些發現提示母性照顧可能通過神經肽Y及其受體控制焦慮和能量平衡。
doi:10.1073/pnas.1109468108
PMC:
PMID:
Regulatory functions of limbic Y1 receptors in body weight and anxiety uncovered by conditional knockout and maternal care
Ilaria Bertocchi, Alessandra Oberto, Angela Longo, Paolo Mele, Marianna Sabettab, Alessandro Bartolomucci, Paola Palanzad, Rolf Sprengele, Carola Eva
Neuropeptide Y （NPY） plays an important role in stress, anxiety, obesity, and energy homeostasis via activation of NPY-Y1 receptors （Y1Rs） in the brain. However, global knockout of the Npy1r gene has low or no impact on anxiety and body weight. To uncover the role of limbic Y1Rs, we generated conditional knockout mice in which the inactivation of the Npy1r gene was restricted to excitatory neurons of the forebrain, starting from juvenile stages （Npy1rrfb）. Npy1rrfb mice exhibited increased anxiety and reduced body weight, less adipose tissue, and lower serum leptin levels. Npy1rrfb mutants also had a hyperactive hypothalamic-pituitary-adrenocortical axis, as indicated by higher peripheral corticosterone and higher density of NPY immunoreactive fibers and corticotropin releasing hormone immunoreactive cell bodies in the paraventricular hypothalamic nucleus. Importantly, through fostering experiments, we determined that differences in phenotype between Npy1rrfb and Npy1r2lox mice became apparent when both genotypes were raised by FVB/J but not by C57BL/6J dams, suggesting that limbic Y1Rs are key targets of maternal care-induced programming of anxiety and energy homeostasis.
