BRCA2 rabbit pAb
- 公司名稱 上海貝博生物科技有限公司
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- 廠商性質 生產廠家
- 更新時間 2025/7/15 7:27:15
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Source
Rabbit
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Applications
IHC,ELISA
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Reactivity
Human,Rat
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Dilution
IHC: 1:100 - 1:300. ELISA: 1:20000. Not yet tested in other applications.
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Storage
-20°C/1 year
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Specificity
BRCA2 Polyclonal Antibody detects endogenous levels of BRCA2 protein.
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Source/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Immunogen
The antiserum was produced against synthesized peptide derived from human BRCA2. AA range:31-80
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Uniprot No
P51587
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Alternative names
BRCA2; FACD; FANCD1; Breast cancer type 2 susceptibility protein; Fanconi anemia group D1 protein
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Form
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Clonality
Polyclonal
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Isotype
IgG
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Background
BRCA2, DNA repair associated(BRCA2) Homo sapiens Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strａnd DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008],
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Other
BRCA2, Breast cancer type 2 susceptibility protein
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Mol.Wt (Da)
384225
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Concentration
1 mg/ml
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