BARD1 rabbit pAb
- 公司名稱 上海貝博生物科技有限公司
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- 型號
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- 廠商性質 生產廠家
- 更新時間 2025/7/14 20:44:19
- 訪問次數 33
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Source
Rabbit
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Applications
WB,IHC,ELISA
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Reactivity
Human
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Dilution
WB: 1:500 - 1:2000. IHC: 1:100 - 1:300. ELISA: 1:5000. Not yet tested in other applications.
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Storage
-20°C/1 year
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Specificity
BARD1 Polyclonal Antibody detects endogenous levels of BARD1 protein.
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Source/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Immunogen
The antiserum was produced against synthesized peptide derived from human BARD1. AA range:1-50
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Uniprot No
Q99728
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Alternative names
BARD1; BRCA1-associated RING domain protein 1; BARD-1
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Form
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Clonality
Polyclonal
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Isotype
IgG
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Background
BRCA1 associated RING domain 1(BARD1) Homo sapiens This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gen
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Other
BARD1, BRCA1-associated RING domain protein 1
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Mol.Wt (Da)
86648
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Concentration
1 mg/ml
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