AS160 (phospho-Ser588) rabbit pAb
- 公司名稱 上海貝博生物科技有限公司
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Source
Rabbit
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Applications
WB
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Reactivity
Human,Mouse
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Dilution
WB 1:1000-2000
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Storage
-20°C/1 year
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Specificity
This antibody detects endogenous levels of Human Mouse AS160 (phospho-Ser588)
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Source/Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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Immunogen
Synthesized phosho peptide around human AS160 (Ser588)
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Uniprot No
O60343
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Alternative names
TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160)
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Form
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Clonality
Polyclonal
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Isotype
IgG
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Background
TBC1 domain family member 4(TBC1D4) Homo sapiens This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Ph
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Other
TBC1D4 AS160 KIAA0603, AS160 (Ser588)
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Concentration
1 mg/ml
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