ASAH3 rabbit pAb
- 公司名稱 上海貝博生物科技有限公司
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- 更新時間 2025/7/14 18:39:42
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Source
Rabbit
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Applications
WB,ELISA
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Reactivity
Human
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Dilution
WB: 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
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Storage
-20°C/1 year
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Specificity
ASAH3 Polyclonal Antibody detects endogenous levels of ASAH3 protein.
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Source/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Immunogen
Synthesized peptide derived from ASAH3 . at AA range: 100-180
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Uniprot No
Q8TDN7
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Alternative names
ACER1; ASAH3; Alkaline ceramidase 1; AlkCDase 1; Alkaline CDase 1; Acylsphingosine deacylase 3; N-acylsphingosine amidohydrolase 3
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Form
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Clonality
Polyclonal
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Isotype
IgG
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Background
alkaline ceramidase 1(ACER1) Homo sapiens Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010],
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Other
ACER1, Alkaline ceramidase 1; Alkaline CDase 1; Acylsphingosine deacylase 3; N-acylsphingosine amidohydrolase 3
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Mol.Wt (Da)
31095
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Concentration
1 mg/ml
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