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Bag-3 rabbit pAb2
- 公司名稱 上海貝博生物科技有限公司
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Source
Rabbit
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Applications
WB,IHC,ELISA
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Reactivity
Human,Mouse,Rat
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Dilution
WB: 1:500 - 1:2000. IHC: 1:100 - 1:300. ELISA: 1:40000. Not yet tested in other applications.
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Storage
-20°C/1 year
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Specificity
Bag-3 Polyclonal Antibody detects endogenous levels of Bag-3 protein.
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Source/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Immunogen
The antiserum was produced against synthesized peptide derived from human BAG3. AA range:411-460
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Uniprot No
O95817
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Alternative names
BAG3; BIS; BAG family molecular chaperone regulator 3; BAG-3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; Docking protein CAIR-1
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Form
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Clonality
Polyclonal
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Isotype
IgG
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Background
BCL2 associated athanogene 3(BAG3) Homo sapiens BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008],
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Other
BAG3, BAG family molecular chaperone regulator 3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; Docking protein CAIR-1
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Mol.Wt (Da)
61595
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Concentration
1 mg/ml
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