ATF6A rabbit pAb
- 公司名稱 上海貝博生物科技有限公司
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- 更新時間 2025/7/14 10:57:09
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Source
Rabbit
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Applications
WB
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Reactivity
Human
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Dilution
WB 1：500-2000
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Storage
-20°C/1 year
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Specificity
This antibody detects endogenous levels of ATF6A at Human
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Source/Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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Immunogen
Synthesized peptide derived from human ATF6A
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Uniprot No
P18850
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Form
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Clonality
Polyclonal
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Isotype
IgG
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Background
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011],
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Other
ATF6, ATF6A
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Mol.Wt (Da)
73700
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Concentration
1 mg/ml
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