Atm (phospho Ser1981) rabbit pAb
- 公司名稱 上海貝博生物科技有限公司
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- 廠商性質 生產廠家
- 更新時間 2025/7/14 10:05:06
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Source
Rabbit
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Applications
WB,IHC,ELISA
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Reactivity
Human,Mouse
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Dilution
WB: 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
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Storage
-20°C/1 year
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Specificity
Phospho-Atm (S1981) Polyclonal Antibody detects endogenous levels of Atm around the phosphorylation site of S1981 protein.
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Source/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Immunogen
Synthesized phospho-peptide around the phosphorylation site of human Atm (phospho Ser1981)
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Uniprot No
Q13315
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Alternative names
ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
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Form
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Clonality
Polyclonal
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Isotype
IgG
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Background
ATM serine/threonine kinase(ATM) Homo sapiens The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010],
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Other
ATM, Serine-protein kinase ATM
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Concentration
1 mg/ml
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