Bag-4 rabbit pAb
- 公司名稱 上海貝博生物科技有限公司
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- 廠商性質 生產廠家
- 更新時間 2025/7/13 19:59:14
- 訪問次數 46
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Source
Rabbit
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Applications
WB,IHC,ELISA
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Reactivity
Human,Mouse,Rat
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Dilution
WB: 1:500 - 1:2000. IHC: 1:100 - 1:300. ELISA: 1:40000. Not yet tested in other applications.
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Storage
-20°C/1 year
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Specificity
Bag-4 Polyclonal Antibody detects endogenous levels of Bag-4 protein.
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Source/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Immunogen
Synthesized peptide derived from the C-terminal region of human Bag-4.
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Uniprot No
O95429
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Alternative names
BAG4; SODD; BAG family molecular chaperone regulator 4; BAG-4; Bcl-2-associated athanogene 4; Silencer of death domains
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Form
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Clonality
Polyclonal
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Isotype
IgG
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Background
BCL2 associated athanogene 4(BAG4) Homo sapiens The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct
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Other
BAG4, BAG family molecular chaperone regulator 4; Bcl-2-associated athanogene 4; Silencer of death domains
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Mol.Wt (Da)
49594
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Concentration
1 mg/ml
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