53BP1 rabbit pAb2
- 公司名稱 上海貝博生物科技有限公司
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- 廠商性質 生產廠家
- 更新時間 2025/7/12 17:26:33
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Source
Rabbit
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Applications
IHC,ELISA
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Reactivity
Human
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Dilution
IHC: 1:100 - 1:300. ELISA: 1:5000. Not yet tested in other applications.
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Storage
-20°C/1 year
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Specificity
53BP1 Polyclonal Antibody detects endogenous levels of 53BP1 protein.
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Source/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Immunogen
The antiserum was produced against synthesized peptide derived from human TP53BP1. AA range:1744-1793
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Uniprot No
Q12888
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Alternative names
TP53BP1; Tumor suppressor p53-binding protein 1; 53BP1; p53-binding protein 1; p53BP1
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Form
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Clonality
Polyclonal
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Isotype
IgG
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Background
function:May have a role in checkpoint signaling during mitosis (By similarity). Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.,PTM:Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.,PTM:Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation.,similarity:Contains 2 BRCT domains.,subcellular location:Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stａnd breaks. Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strａnd breaks.,subunit:Interacts with IFI202A (By similarity). Binds to the central domain of TP53/p53. May form homo-oligomers. Interacts with DCLRE1C. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on 'Ser-139'. Interacts with histone H4 that has been dimethylated at 'Lys-20'. Has low affinity for histone H4 containing monomethylated 'Lys-20'. Does not bind histone H4 containing unmethylated or trimethylated 'Lys-20'. Has low affinity for histone H3 that has been dimethylated on 'Lys-79'. Has very low affinity for histone H3 that has been monomethylated on 'Lys-79' (in vitro). Does not bind unmethylated histone H3.,
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Other
TP53BP1, Tumor suppressor p53-binding protein 1
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Mol.Wt (Da)
213574
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Concentration
1 mg/ml
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