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53BP1 rabbit pAb

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  • 公司名稱 上海貝博生物科技有限公司
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  • 更新時(shí)間 2025/7/12 17:16:32
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        貝博生物專注于生命科學(xué)研究用試劑產(chǎn)品的研究、開發(fā)、市場(chǎng)推廣和技術(shù)服務(wù)。致力于為中國(guó)廣大客戶提供量身定制的科研用試劑產(chǎn)品和專業(yè)技術(shù)服務(wù),幫助科研人員加速生物領(lǐng)域的研究進(jìn)展。 貝博生物將以高品質(zhì)的產(chǎn)品和服務(wù)打造中國(guó)*實(shí)力的試劑品牌。

      目前已上市了600多種蛋白提取試劑盒(動(dòng)物、植物、細(xì)菌、昆蟲、酵母等樣本及細(xì)胞器提取)及上千種的細(xì)胞檢測(cè)的相關(guān)產(chǎn)品-細(xì)胞凋亡、增殖毒性、細(xì)胞周期、膜電位檢測(cè)、細(xì)胞器熒光探針、活性氧ROS檢測(cè)、細(xì)胞自噬、細(xì)胞耗氧OCR、細(xì)胞外酸化率ECAR、缺氧檢測(cè)、粘附檢測(cè)、鈣離子檢測(cè)、膜通透性轉(zhuǎn)換孔檢測(cè)、膜流動(dòng)性檢測(cè)、外泌體、囊泡提取等。

 

蛋白提取,細(xì)胞分析

  • Source

    Rabbit

  • Applications

    WB,IHC,IF,ELISA

  • Reactivity

    Human,Mouse,Rat

  • Dilution

    WB: 1:500 - 1:2000. IHC: 1:100 - 1:300. IF: 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

  • Storage

    -20°C/1 year

  • Specificity

    53BP1 Polyclonal Antibody detects endogenous levels of 53BP1 protein.

  • Source/Purification

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen

    The antiserum was produced against synthesized peptide derived from human 53BP1. AA range:1-50

  • Uniprot No

    Q12888

  • Alternative names

    TP53BP1; Tumor suppressor p53-binding protein 1; 53BP1; p53-binding protein 1; p53BP1

  • Form

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Clonality

    Polyclonal

  • Isotype

    IgG

  • Background

    function:May have a role in checkpoint signaling during mitosis (By similarity). Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.,PTM:Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.,PTM:Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation.,similarity:Contains 2 BRCT domains.,subcellular location:Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand breaks.,subunit:Interacts with IFI202A (By similarity). Binds to the central domain of TP53/p53. May form homo-oligomers. Interacts with DCLRE1C. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on 'Ser-139'. Interacts with histone H4 that has been dimethylated at 'Lys-20'. Has low affinity for histone H4 containing monomethylated 'Lys-20'. Does not bind histone H4 containing unmethylated or trimethylated 'Lys-20'. Has low affinity for histone H3 that has been dimethylated on 'Lys-79'. Has very low affinity for histone H3 that has been monomethylated on 'Lys-79' (in vitro). Does not bind unmethylated histone H3.,

  • Other

    TP53BP1, Tumor suppressor p53-binding protein 1

  • Mol.Wt (Da)

    213574

  • Concentration

    1 mg/ml

Product Reactivity Applications Conjugation Catalog Images

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