53BP1 rabbit pAb
- 公司名稱 上海貝博生物科技有限公司
- 品牌
- 型號(hào)
- 產(chǎn)地
- 廠商性質(zhì) 生產(chǎn)廠家
- 更新時(shí)間 2025/7/12 17:16:32
- 訪問次數(shù) 253
聯(lián)系方式:張經(jīng)理18930271235 查看聯(lián)系方式
聯(lián)系我們時(shí)請(qǐng)說明是化工儀器網(wǎng)上看到的信息,謝謝!
-
Source
Rabbit
-
Applications
WB,IHC,IF,ELISA
-
Reactivity
Human,Mouse,Rat
-
Dilution
WB: 1:500 - 1:2000. IHC: 1:100 - 1:300. IF: 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
-
Storage
-20°C/1 year
-
Specificity
53BP1 Polyclonal Antibody detects endogenous levels of 53BP1 protein.
-
Source/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
Immunogen
The antiserum was produced against synthesized peptide derived from human 53BP1. AA range:1-50
-
Uniprot No
Q12888
-
Alternative names
TP53BP1; Tumor suppressor p53-binding protein 1; 53BP1; p53-binding protein 1; p53BP1
-
Form
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
-
Clonality
Polyclonal
-
Isotype
IgG
-
Background
function:May have a role in checkpoint signaling during mitosis (By similarity). Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.,PTM:Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.,PTM:Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation.,similarity:Contains 2 BRCT domains.,subcellular location:Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand breaks.,subunit:Interacts with IFI202A (By similarity). Binds to the central domain of TP53/p53. May form homo-oligomers. Interacts with DCLRE1C. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on 'Ser-139'. Interacts with histone H4 that has been dimethylated at 'Lys-20'. Has low affinity for histone H4 containing monomethylated 'Lys-20'. Does not bind histone H4 containing unmethylated or trimethylated 'Lys-20'. Has low affinity for histone H3 that has been dimethylated on 'Lys-79'. Has very low affinity for histone H3 that has been monomethylated on 'Lys-79' (in vitro). Does not bind unmethylated histone H3.,
-
Other
TP53BP1, Tumor suppressor p53-binding protein 1
-
Mol.Wt (Da)
213574
-
Concentration
1 mg/ml
Product | Reactivity | Applications | Conjugation | Catalog | Images |
---|